ANCOVA of Change from Baseline at Week 20
Missing Data Approach
Analysis Population


Baseline

Week 20

Change from Baseline

Treatment

N

Mean (SD)

N

Mean (SD)

N

Mean (SD)

LS Mean (95% CI)a

Study Drug

61

16.6 (4.41)

61

-6.6 (5.95)

61

-7.0 (9.16)

-7.0 (-8.58, -5.38)

Placebo

70

18.4 (6.34)

70

-9.0 (7.04)

70

-8.7 (8.54)

-8.7 (-10.17, -7.18)

Pairwise Comparison

Difference in LS Mean (95% CI)a

p-Value

Study Drug vs. Placebo

1.7 (-0.49, 3.88)

0.130

Root Mean Squared Error of Change = 6.23

aBased on an ANCOVA model.
ANCOVA = Analysis of Covariance, CI = Confidence Interval, LS = Least Squares, SD = Standard Deviation

Source: [study999: adam-adeff]